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Department of Quantitative Biomedicine

The Bodenmiller group publishes their collaborative work on dysregulation of T cell homeostasis and function in severe COVID-19

Profound dysregulation of T cell homeostasis and function in patients with severe COVID-19

Fig.1D. T-SNE plots of normalized marker expression
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Fig.1D. T-SNE plots of normalized marker expression © The Authors

This prospective multicenter cohort study revealed profound perturbations of peripheral T cell homeostasis and function in severe COVID‐19 compared to mild disease, through cross‐sectional analysis of phenotypic and functional characteristics of T cells in patients with mild and severe COVID‐19, using 40‐parameter mass cytometry, flow cytometry, targeted proteomics, and functional assays.

This work results from a collaboration between the groups of Bernd Bodenmiller and Jakob Nilsson and Onur Boyman at the Department of Immunology, University Hospital Zurich (USZ).

See Adamo et al., Allergy

N.B. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. 

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